Glucocorticoid-induced apoptosis: a simple set of laboratory experiments
نویسندگان
چکیده
منابع مشابه
Role of mitochondrial glucocorticoid receptor in glucocorticoid-induced apoptosis
The mechanisms by which glucocorticoid receptor (GR) mediates glucocorticoid (GC)-induced apoptosis are unknown. We studied the role of mitochondrial GR in this process. Dexamethasone induces GR translocation to the mitochondria in GC-sensitive, but not in GC-resistant, T cell lines. In contrast, nuclear GR translocation occurs in all cell types. Thymic epithelial cells, which cause apoptosis o...
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Glucocorticoids (GCs) cause cell cycle arrest and apoptosis in lymphoid cells which is exploited to treat lymphoid malignancies. The mechanisms of these anti-leukemic GC effects are, however, poorly understood. We previously defined a list of GC-regulated genes by expression profiling in children with acute lymphoblastic leukemia (ALL) during systemic GC monotherapy and in experimental systems ...
متن کاملSpecific inhibition of glucocorticoid-induced thymocyte apoptosis by substance P.
Glucocorticoids (GC) are strong inducers of thymocyte apoptosis. In the present study we looked into the possibility that the neuropeptide substance P (SP) might serve as an antagonist to GC-induced apoptosis. Indeed, SP inhibited hydrocortisone (HC)-induced apoptosis of CD4+CD8+ thymocytes in mice, both in vivo and in vitro. It also inhibited HC-induced apoptosis in the T cell hybridoma line 2...
متن کاملRegulation of a distinctive set of genes in glucocorticoid-evoked apoptosis in CEM human lymphoid cells.
Gene expression was evaluated in clones of the acute lymphoblastic leukemic cell line CEM that were sensitive or resistant to apoptosis evoked by the glucocorticoid, dexamethasone (Dex). Founding clones CEM-C7 (glucocorticoid sensitive) and CEM-C1 (glucocorticoid resistant) were subcloned to maximize uniformity of each population studied. Among subclones of C1, our original pseudodiploid clone ...
متن کاملMolecular Mechanisms Conferring Resistance/Sensitivity to Glucocorticoid-Induced Apoptosis
© 2012 Berrou et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Molecular Mechanisms Conferring Resistance/Sensitivity to Glucocorticoid-Induced Apop...
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ژورنال
عنوان ژورنال: Biochemistry and Molecular Biology Education
سال: 2000
ISSN: 1470-8175,1539-3429
DOI: 10.1111/j.1539-3429.2000.tb00180.x